System dynamics modeling offers great promise for examining and addressing persistent problems like HIV and other sexually transmitted infection (STI) epidemics. Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding of and to harness the forces of change within complex, multilevel systems that impact upon intervention implementation, effects, and sustainability ( Foster-Fishman & Behrens, 2007 Hawe et al., 2009 Hirsch, Levine, & Miller, 2007 Homer et al., 2010 Latkin et al., 2010 Meadows, 2008 Trickett et al., 2011). Effective interventions aimed at reducing high risk behavior, such as having unprotected sex with multiple partners or sharing syringes and other drug injection paraphernalia, must include strategies to address the broader social, political, and environmental context in which these risk behaviors occur ( Latkin et al., 2010 Trickett et al., 2011). Over 30 years of HIV prevention research has demonstrated the need to take an ecological approach in order to understand and address the complex, layered factors that both generate and can eliminate the epidemic globally and locally ( Evans & Lambert, 2008 Hawe, Shiell, & Riley, 2009 Latkin, Weeks, Glasman, Galletly, & Albarracin, 2010 Schensul & Trickett, 2009 Trickett, 2005 Trickett et al., 2011). We present the conceptual system dynamics model and discuss how further testing in this and other settings can inform future community interventions to reduce HIV and STIs. Multiple feedback loops in the sex-work establishments, women’s social networks, and the health organization responsible for implementing HIV/STI interventions in each town and at the town level directly or indirectly influenced the FC intervention. To build this conceptual model, we drew on our experiences and findings from this intensive, longitudinal mixed ethnographic and quantitative four-town comparative case study (2007–2012) of the sex-work establishments, the intervention conducted in them, and factors likely to explain variation in process and outcomes in the four towns. The model reflects factors and forces affecting the study’s intervention implementation and effects. We generated a system dynamics model of a multilevel intervention we conducted to promote female condoms (FC) for HIV/STI prevention among Chinese women in sex-work establishments. System dynamics modeling offers great promise for addressing persistent problems like HIV and other sexually transmitted epidemics, particularly in complex rapidly developing countries like China. Building a system dynamics model based on ethnographic case study has the advantage of using empirically documented contextual factors and processes of change in a real world and real time setting that can then be tested in the same and other settings. Social and public health scientists are increasingly interested in applying system dynamics theory to improve understanding and to harness the forces of change within complex, multilevel systems that affect community intervention implementation, effects, and sustainability.
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This park is one of DC's largest recreation areas with 1,200 acres of green space and beautiful groves of blooming trees. The trees were planted in 1943 outside of the old School of International Service, now renamed as the East Quad Building, blooming each year as a plaque testifying to the AU-Korean friendship. It's a little known secret that AU has an arboretum and is home to more than 75 different tree species, including the Korean Cherry. Capitol Columns in the background make an ideal Instagram moment. So trees are basically identical to the ones at the Tidal Basin, but you can enjoy them without all the crowds. Cuttings of the original 1912 cherry blossom trees were taken by the Arboretum in order to preserve their genetic lineage. National Arboretum covers its 446 acres with dogwoods, crape myrtle trees, a bonsai museum, and, best of all, a collection of cherry trees, including some hybrid species bred by staff scientists. Fun fact: The cherry blossoms here are genetic cousins to the ones at the Tidal Basin. One of the city’s best kept Cherry Blossom secrets is the US National Arboretum, which is one of my favorites! The U.S. There isn't a central place to see all the trees all at once, but it's a lovely place to see the pink and white blooms in all their glory on a leisurely stroll or bike ride. The cherry blossom-lined streets in this neighborhood near Georgetown are one of the city's best kept secret. Parking is also a bear in this neighborhood so we recommend you walk or take the bus. There is an $8 admission fee for this one that goes to support the gardens. In fact, there's a special place called Cherry Hill in the garden. Quick history lesson: the plantings of the cherry trees at the Tidal Basin originated in 1912 as a gift of friendship to the People of the United States from the People of Japan. In Japan, the flowering cherry tree, or "Sakura," is an exalted flowering plant.ĭ umbarton Oaks has a marvelous orchard of cherry trees. There is a grouping of more than 100 cherry blossom trees lining the fountain and pathways in Lower Senate Park, which is located north of the Capitol Building. Most of the West Lawn of the Capitol also has a variety of Cherry Blossom trees so you’ll be able to get a great photo of the blooms up close surrounding the Capitol dome.įittingly, the walls of the granite memorial, which commemorates the loyalty and patriotism of Japanese American veterans in World War II and remembers Japanese Americans held unlawfully in internment camps, are flanked by cherry trees. (#nofilter) The steps of the Jefferson Memorial provide a beautiful 180-degree view of the tree lined tidal basin. Add Cherry Blossoms into the mix and you have the recipe for a perfect Instagram-ready photo. The view from the steps of the Jefferson Memorial–in any season–is one of our favorite spots in Washington. An hour was plenty of time to enjoy the Basin and Blossoms.In honor of the centennial celebration, Japan gifted the city an additional 100 cherry blossoms that have been planted in groves around the Washington Monument. It took us 15 minutes to get to the MLK side, pedaling into the breeze, but once there, it was a leisurely pedal around the Basin with the wind at our backs. The boats are clean and easy to pedal, unless, you want to get across the Tidal Basin within the hour, your legs will get tired. You can pay online and sign your waivers ahead of time, so check in at the dock is a breeze. During this busy season, make a reservation, there are a lot of time slots available. The employees were helpful and efficient, and we enjoyed pedaling around the basin, taking a breather from the crowds. Riding on the boat was a perfect way to view the blossoms, away from the crowds. We did our boat ride on Sunday, March 26, the day that literally a million visitors came to enjoy the cherry blossoms at their peak bloom, on the first clear, beautiful blue sky spring day. He was able to move my reservation up to an earlier time. I emailed Paul and he responded within seconds. After booking a specific time, I realized that I needed an earlier time. Runewords convert Armor or Weapons in Unique Equipment once the required amount of Runes is placed in the correct order, granting said item a fixed set of properties. Infinity is a Diablo 2 Resurrected runeword created by combining ber + mal + ber + ist into a 4 socket polearm or spear. 50 Chance to Cast Level 20 Chain Lightning When You Kill An Enemy Level 12 Conviction Aura When Equipped +35 Faster Run/Walk +255-325 Enhanced Damage (varies) - (45-55) to Enemy Lightning Resistance (varies) 40 Chance of Crushing Blow Prevent Monster Heal + (0. Hammerdin is no longer the fastest (though it's still up to debate) since blizzard removed ignore magic immunity for undead, so the second wave of baal minions takes longer now, but he's still the safest due to high def and hit recovery. Doom can be applied to Axes, Hammers or Polearms, and is composed of five Runes. Infinity on the sorc herself is not a good idea, because you miss out a lot of +skills and other stats (FCR, res) on your weapon and shield, the minus target light res doesnt make up for them much, especially not for fire/cold spells, and the radius of the Conviction aura limits your range of attacks. Personally it took around 2 months (1.5 months of LK runs) to get enough sur runes. 5% Chance to Cast Level 18 Volcano on Strikingĭoom is a Runewords in Diablo 2. Infinity can be applied to Polearms and is composed of 4 Runes. 50 Chance to Cast Level 20 Chain Lightning When You Kill An. Photo: DigiBujo Notes Photo: DigiBujo Draw Photo: DigiBujo Math DATED Outline Planner – for iPad, fully-dated Read the full side-by-side comparison between the best apps here: The Notability and Goodnotes apps are also good options because they allow you to add photos and drawings to your digital journal entries.Noteshelf is my preferred app for bullet journaling because it’s friendly and easy, and it allows me to set up an accessible favorite pens toolbar.These apps can be just as natural and easy to use as writing on paper, especially if you’re using a paper-like screen protector: Goodnotes 5, Noteshelf and Notability I’m going to tell you about the best three note-taking apps for iOS that let you create digital planners. Photo: People Planner Best note apps for bullet journaling Experiment with different methods and see what works best for you. Whether you decide to use a simple digital notebook, or buy the best bullet journals for iPad the most important thing is finding a system that works for you. There are many different ways to get started with a bullet journal.
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He stressed that the military action would not stop until military forces inside the Nagorno-Karabakh disarm and “raise a white flag.”Īzerbaijan’s defense ministry demanded in a statement Tuesday “the complete withdrawal of ethnic Armenian troops and the dissolution of the government in Stepanakert” and said only “legitimate military targets are being incapacitated.” “The Azerbaijani government has made a decision to start with an unlimited, but local counterterrorism actions and measures on the ground to neutralize finally the military installations of military infrastructure that illegally exists on our territory,” Hajiyev said. Hajiyev also said that Azerbaijan’s “counterterrorism action” against Nagorno-Karabakh’s Defense Army was triggered by the death of six people in landmine explosions inside Azerbaijan, including two civilians and four police officers. Siranush Sargsyan/APĪn Azerbaijani presidential adviser on Tuesday played down reports of civilian casualties inside Nagorno-Karabakh, but said “collateral damage” is a possibility in any military operation.Ĭonfronted with reports of civilian casualties during Azerbaijan’s military operation in the disputed region on Tuesday, Hikmet Hajiyev, a political adviser to the president of Azerbaijan, told CNN’s Matthew Chance in an exclusive interview that he doubted their accuracy. Otherwise, anti-terrorist measures will be continued until the end.”ĬNN has been unable to verify the claims of either side in the conflict.Ī girl embraces her relative sitting in a shelter during shelling in Stepanakert, Nagorno-Karabakh. In response, the Azerbaijani Presidency said it is willing to meet with Karabakh Armenians, but added in a statement: “To stop anti-terrorist measures, illegal Armenian armed groups must raise the white flag, surrender all weapons, and the illegal regime must dissolve itself. Karabakh authorities said they have asked for immediate talks with Azerbaijan, amid continued shelling of the region. But Moscow has been accused of being unable or unwilling to intervene to protect Armenia, its long-term ally, in the face of continuing aggression from Azerbaijan. Russian peacekeepers, who deployed to Nagorno-Karabakh under the terms of the 2020 ceasefire, have been tasked with preventing a fresh conflict breaking out. Tensions have been simmering around the region for months, after Azerbaijani troops blockaded the Lachin corridor in December, cutting off the only road connecting Nagorno-Karabakh to Armenia and preventing the import of food to its roughly 120,000 inhabitants. The office of the ombudsman in Nagorno-Karabakh said at least 200 people had died, including ten confirmed civilian deaths and five children, in a statement online late on Wednesday, after Armenian media and local authorities reported heavy bombardment of the regional capital of Stepanakert. At least 200 people have been killed and over 400 others wounded in a military operation by Azerbaijan in the disputed Nagorno-Karabakh region, according to an official in Armenian-controlled territory there.Īzerbaijan’s defense ministry said Tuesday it had begun an “anti-terrorist” campaign in the region, an ethnic Armenian enclave that is internationally recognized as part of Azerbaijan and which has been the cause of two wars between the neighbors in the past three decades, most recently in 2020. Oxton said the company will serve beer from a fully-refrigerated, 24-tap beer trailer. Night Shift plans to open the first location, dubbed “The Owl’s Nest,” on Boston’s Esplanade in early August. However, Oxton said both sides have interest in continuing the partnership, if it’s successful. “For us, we’re trying to look at this as a long-term partnership,” he said, noting that the partnership isn’t currently slated to extend beyond this year’s run of early August through October. Oxton said the company had been scouting locations for potential beer gardens for about a year but hadn’t found the “right fit” before the DCR and Esplanade Association announced a request-for-proposal process for the two sites about a month ago. “It brings people to two totally different settings,” he said.Īs part of the Night Shift deal, the company will partner with the Massachusetts Department of Conservation & Recreation (DCR) and the Esplanade Association and give a portion of proceeds from beer and wine sales to both organizations. In fact, 23 percent of millennials surveyed said they bought craft beer in third spaces while 17 percent of all legal-drinking age consumers made their purchases in third spaces.Īccording to Oxton, the pop-up taprooms create another place for craft beer drinkers to interact with their favorite brands. “Pop-ups can be a part of that, but they certainly aren’t the only way or a universal solution.”Īdditionally, Nielsen CGA’s Beverage Alcohol Generations Study found that millennials are making more craft beer purchases in third spaces. “As the general ‘third-space’ trend shows, brand building is moving in an increasingly interactive and experiential direction,” Watson wrote in an email to Brewbound. First off, adequate drainage is a must, especially if you plan to put them outside. When it comes to growing succulents in pots, it’s important to choose the right container. Learn exactly how and when to water them here. So if you struggle with it, I highly recommend buying an inexpensive moisture gauge to make it super easy for you. This is one the most important things to get right. If it feels wet at all, then wait longer. To check it, stick your finger at least 2″ deep. The soil should be completely dry before add more. So always, always check to make sure they actually need it first. They hate wet feet, and consistent overwatering will cause them to rot and die. And guess what, overwatering is their #1 killer. Proper watering is by far the hardest part of successful succulent plant care for most people. Related Post: How To Plant Succulents Indoors Or OutsideĪ few different succulents growing in a pot together Water Choose a container with holes in the bottom, or a garden area that doesn’t get much rain. They do equally well in pots as they do in the ground, as long as these conditions are met. No matter if you want to grow them indoors or outside, it’s very important to keep succulents in a dry location where they will get bright light. While others would quickly die at the first sign of frost, and must be kept indoors during the winter. I have some that can survive several months of sub-zero temps in my zone 4 MN garden. Their native habitat is the desert, which can get pretty chilly at night, even below freezing at times.īut the exact hardiness depends on the species. You might be surprised to learn that most succulents are fairly cold hardy. Understanding their hardiness, and placing them in the right location are the first steps for success. How To Grow Succulentsīefore I get into the specific details of succulent care, let’s talk about where to grow them. The ASPCA website has a good list to start with. So, if you’re concerned about their safety, then I recommend researching the specific variety that you have. Unfortunately some of them can be poisonous, while others are completely non-toxic. I often get asked if succulents are toxic to cats and dogs. This means they require less maintenance from us. Since they are good at storing water, they don’t need as much moisture as other types of plants. They are native to arid climates that don’t get much rain. Do succulents grow better inside or outside?Ī succulent is a type of plant that has plump, firm leaves and stems which are designed to retain water.Troubleshooting Common Succulent Care Problems. Despite improvements in OSCC diagnosis and treatment, almost half of patients with OSCC die within five years of diagnosis. Recently, the incidence and mortality rates of OSCC are increasing worldwide, and this increase in mortality rate is associated with regional and distant metastasis, which leads to a worse prognosis. Oral squamous cell carcinoma (OSCC) is a disease with increasing incidence worldwide that leads to deformity and death. In OSCC, FSCN1 is likely to be a biomarker and therapeutic target. In conclusion, our study investigated the functions and mechanisms of the FSCN1/IRF4/AKT pathway in OSCC progression. Mechanistic studies showed that FSCN1 achieves its function partially by activating interferon regulatory factor 4 (IRF4) and the AKT pathway in OSCC. FSCN1 silencing remarkably suppressed OSCC glycolysis. In addition, colony formation, CCK-8, and transwell assays revealed a notable reduction in OSCC growth and invasion when FSCN1 was silenced. ResultsįSCN1 was remarkably overexpressed in OSCC tissues and cell lines compared to corresponding controls. Western blotting was used to confirm the interaction of FSCN1, IRF4 and AKT. Moreover, glucose consumption was detected. The role of FSCN1 was also assessed in vitro through colony formation, CCK-8, and transwell assays. We used qRT‒PCR to detect the expression of FSCN1 in 40 paired OSCC tumor tissues (tumor) and neighboring noncancerous tissues. However, the functions and potential mechanisms of FSCN1 in the OSCC tumorigenesis process have not been reported thus far. In OSCC, fascin actin-bundling protein 1 (FSCN1) is an oncogene involved in the tumorigenesis process. It's not the most efficient at reading all of the data on your device, but what it does display is well organized.Įditors' note: This is a review of the trial version of iRip for Mac 2.1.7.Oral squamous cell carcinoma (OSCC) is a disease with increasing incidence worldwide that leads to deformity and death. IRip is a handy little program for managing the transfer of media between your computer and your iOS devices. If you're looking for something along the lines of a Quick Start Guide, or if the problem you're having doesn't fit into one of the included categories, you're out of luck. Inadequate Help: The Help link only takes you to a FAQs page with about nine general entries. There is no way to refresh a connection while a device remains plugged in. Music was also not present at all the first time the device was connected, and we had to disconnect and reconnect before it showed up. Incomplete recognition: Although a People category was created when we connected an iPhone through the app, no Contacts were imported. Photos are displayed as thumbnails, so you can easily see which ones you want to save, and Playlists are shown separately below the main categories, making them easy to navigate as well. Good organization: Files are organized into categories including Music, Photos, and People, and clicking on one of these allows you to view all of the included details. Transfers are speedy as well, so you don't have to worry about blocking out a lot of time to finish what you start in this app. Quick readings: When you connect your iOS device to this app, it quickly completes a scan of the contents and displays it in the main interface window. Through this program, you can save photos, organize your music, and connect to iTunes, if you choose. IRip is a program that lets you transfer songs, photos, and other media from your iOS device to your computer and save it wherever you choose. |
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